Antimycobacterial Activity and Mechanism of Action of NAS-91.
نویسندگان
چکیده
The antimalarial agents NAS-91 and NAS-21 were found to express potent antimycobacterial activity, NAS-91 being more active than NAS-21. They partially inhibited mycolic acid biosynthesis and profoundly altered oleic acid production. The development of a cell-free assay for Delta 9-desaturase activity allowed direct demonstration of the inhibition of oleic acid biosynthesis by these compounds.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 52 3 شماره
صفحات -
تاریخ انتشار 2008